Manganese, Blood
Use
The test is useful for the evaluation of central nervous system symptoms similar to Parkinson disease in manganese (Mn) miners and processors, characterization of liver cirrhosis, and therapeutic monitoring in treatment of cirrhosis, parenteral nutrition-related Mn toxicity, and environmental exposure to Mn. Manganese is a trace essential element with many industrial uses. High exposure can lead to manganese toxicity, which progresses through several stages of neurological symptoms.
Special Instructions
This specimen container cannot be opened or used for any other testing before shipping. Patient preparation requires avoiding collection if gadolinium- or iodine-containing contrast media has been administered within 96 hours.
Limitations
Whole blood manganese concentrations are not responsive to dietary depletion, but measures of serum Mn are potentially useful. Contamination of the collection site and of the specimen must be avoided, as improper collection can lead to falsely increased results. This test has not been FDA cleared or approved but complies with CLIA requirements.
New York Approved
Methodology
Mass Spectrometry (ICP-MS)
Biomarkers
LOINC Codes
- 5681-2
- 5681-2
Result Turnaround Time
1-5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
1.0 mL
Minimum Volume
0.4 mL
Container
Royal blue-top BD vacutainer with EDTA blood collection tube (3 mL) (BD catalog no. 367777)
Collection Instructions
See Metals Analysis Specimen Collection and Transport for complete instructions. Send whole blood specimen in original tube. Do not aliquot.
Patient Preparation
Avoid collection if gadolinium- or iodine-containing contrast media has been administered within 96 hours.
Causes for Rejection
Contaminated or improperly collected specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 28 days |
| Refrigerated | 28 days |
| Frozen | 28 days |