Manganese, RBC and Plasma
Use
The Manganese, RBC and Plasma test measures the levels of manganese in red blood cells and plasma. Manganese is an essential mineral involved in several critical physiological processes, including amino acid, cholesterol, glucose, and carbohydrate metabolism. However, elevated levels of manganese can be indicative of manganese toxicity, which can affect the nervous system and result in various neurological symptoms. This test is important for detecting abnormal manganese levels that could lead to toxicity or deficiency, which can guide medical interventions and treatment options.
Special Instructions
It is crucial that both packed cells and plasma are collected and separated as soon as possible. The samples must be shipped refrigerated and received at the testing facility within five days of collection to ensure the integrity of the specimens. Failure to meet these requirements may result in the rejection of the sample due to hemolysis of red cells or contamination of the plasma.
Limitations
This test cannot differentiate between manganese bound to different proteins, and it may not reflect the total manganese burden in the body. Hemolysis of blood samples, even if not visible, can falsely elevate plasma manganese concentrations due to the release of manganese from the cellular components of blood.
Methodology
Mass Spectrometry (ICP-MS)
Biomarkers
LOINC Codes
- 87467-7
- 5683-8
- 5682-0
Result Turnaround Time
5-7 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
3 mL
Minimum Volume
0.5 mL
Container
Royal blue-top (EDTA metal-free tube)
Collection Instructions
Both packed cells and plasma are required. Plasma and red cells must be separated ASAP and shipped separately. Transfer RBCs and plasma into separate plastic, acid-washed, trace metal-free tubes. Ship refrigerated.
Causes for Rejection
Hemolysis of red cells; specimen received more than 5 days after collection.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 5 days |