Maternal Cell Contamination, Molecular Analysis, Varies
Use
This test is crucial in identifying maternal cell contamination (MCC) within a fetal specimen. Such contamination can compromise the accuracy of prenatal genetic analyses due to the masking of fetal DNA results by maternal DNA. Hence, this test is mandatory for all prenatal testing conducted in Mayo Clinic Laboratories' Molecular and Biochemical Genetics laboratories. Its role is to rule out MCC, ensuring reliable and accurate genetic test results in the context of prenatal diagnoses.
Special Instructions
The test requires both maternal and fetal specimens to be submitted under separate order numbers. In case of prenatal testing, both sample types must be received to proceed with the testing. If a prenatal specimen has been used in another test, resubmission is not required. Consultation with the laboratory is advised for all prenatal testing inquiries at 800-533-1710.
Limitations
This method does not eliminate the possibility of low-level maternal cell contamination below 5%, which might still affect the accuracy of fetal genetic testing results.
New York Approved
Methodology
PCR-based (PCR)
Biomarkers
LOINC Codes
- 40704-9
- 50397-9
- 40704-9
- 69047-9
- 42349-1
- 31208-2
- 18771-6
- 85069-3
Result Turnaround Time
10-11 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
3 mL
Minimum Volume
Not provided
Container
Lavender top (EDTA) or yellow top (ACD)
Collection Instructions
Invert several times to mix blood. Send whole blood specimen in original tube. Do not aliquot.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 days |
| Refrigerated | 4 days |
| Frozen | 4 days |