MayoComplete Acute Myeloid Leukemia, 11-Gene Panel, Varies
Use
The MayoComplete Acute Myeloid Leukemia, 11-Gene Panel is designed to evaluate somatic mutations that are diagnostically, prognostically, and therapeutically relevant in acute myeloid leukemia (AML). Through next-generation sequencing, this test analyzes mutations in a focused 11-gene panel to better classify AML, provide prognostic insights, and guide therapeutic decisions. It is particularly useful during the diagnostic phase of AML or when the disease is relapsed or refractory, allowing for a more tailored approach to patient management based on specific genetic profiles.
Special Instructions
This test is a subset of the broader NGSHM MayoComplete Myeloid Neoplasms, focusing on the most clinically significant mutations in AML. It is important to provide comprehensive clinical information, including diagnosis, disease phase, and therapy status, when ordering this test, as this information aids in interpretation and clinical correlation. This test requires specific specimen submissions to ensure valid results, including bone marrow aspirate, whole blood, or extracted DNA, and might need to follow rigorous collection and shipping protocols to maintain specimen integrity.
Limitations
The test targets 11 specific genes with variable exon, region, and hot spot coverage. It does not detect mutations outside the targeted regions, gene rearrangements, or large chromosomal alterations. Some detected mutations may represent low-frequency polymorphisms rather than disease-associated mutations, particularly if present in non-malignant cells. Prior hematologic treatments, such as stem cell transplants, may affect the assay's ability to correctly identify somatic mutations. Additional genetic testing and expert consultation may be required for suspected germline mutations or in cases with significant clinical suspicion.
New York Approved
Methodology
NGS (Targeted)
Biomarkers
LOINC Codes
- 105343-8
- 82939-0
- 69047-9
- 82786-5
- 93367-1
- 48767-8
- 85069-3
- 62364-5
- 36908-2
- 18771-6
- 31208-2
Result Turnaround Time
16-21 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
2 mL
Minimum Volume
1 mL
Container
Lavender top (EDTA) or yellow top (ACD), Acceptable: Green top (sodium heparin)
Collection Instructions
Invert several times to mix bone marrow. Send in original tube. Label specimen as bone marrow.
Storage Instructions
Ambient (preferred) 14 days/Refrigerate 14 days
Causes for Rejection
Gross hemolysis, Bone marrow biopsies, Slides, Paraffin shavings or frozen tissues, Paraffin-embedded tissues, Moderately to severely clotted
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |