MayoComplete Gynecological Cancer Panel, Next-Generation Sequencing, Tumor
Use
This test is useful for predicting patients' prognosis and response to targeted therapy, as well as assessing microsatellite instability (MSI) for immunotherapy decisions in patients with gynecologic tumors, including endometrial, ovarian, and sex-cord stromal tumors. The test evaluates somatic mutations within a curated list of 49 genes that are important for clinical management, and assesses DNA damage response genes associated with therapeutic eligibility for poly(adenosine diphosphate-ribose) polymerase inhibitors. It also assists in molecular classification of gynecologic tumors based on current guidelines and World Health Organization recommendations.
Special Instructions
A pathology report containing specific information such as patient name, block number, tissue collection date, and source of the tissue must accompany the specimen for testing to be performed. When this test is ordered, a slide review will always be performed at an additional charge. This test uses formalin-fixed, paraffin-embedded tumor or cytology slides.
Limitations
This test is designed to evaluate somatic mutations and does not assess for germline alterations within the genes listed. It cannot differentiate between somatic and germline alterations. Additional testing may be necessary to clarify the significance of results if there is a potential hereditary risk. A negative result does not rule out the presence of a variant below the detection limits of this assay. It may not detect larger-scale genomic copy number variants or epigenetic modifications. The test cannot reliably determine if a variant in PMS2 exons 11-15 originated from PMS2 or PMS2CL pseudogene, additional testing may be recommended in such cases.
New York Approved
Methodology
NGS (Targeted)
Biomarkers
LOINC Codes
- 105592-0
- 82939-0
- 69047-9
- 48767-8
- 31208-2
- 80398-1
- 85069-3
- 62364-5
- 18771-6
Result Turnaround Time
12-20 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Formalin-fixed, paraffin-embedded tissue block
Collection Instructions
Submit a formalin-fixed, paraffin-embedded tissue block with an acceptable amount of tumor tissue.