MayoComplete Ovarian, Fallopian Tube, and Peritoneal Cancer Panel, Next-Generation Sequencing, Tumor
Use
This test is primarily used to determine if patients with ovarian, fallopian tube, and peritoneal cancer will respond to targeted therapy. It assesses the microsatellite instability (MSI) which is crucial for immunotherapy decisions. The test evaluates somatic mutations within a curated list of DNA damage response genes, including ATM, ATR, BARD1, BRCA1, BRCA2, BRIP1, CDK12, MLH1, MSH2, MSH6, PALB2, PMS2, RAD51C, and RAD51D. This information is useful for assessing prognosis, guiding treatment, and potentially determining eligibility for clinical trials.
Special Instructions
Not provided.
Limitations
This test cannot differentiate between somatic and germline alterations, and further testing may be required if there is a potential hereditary risk. It does not detect multi-exon deletions, duplications, larger-scale genomic variants, or epigenetic modifications. The sensitivity of the assay is limited to detecting variants with at least a 5% mutant allele frequency. Variants observed in PMS2 exons 11-15 may originate from either PMS2 or its pseudogene PMS2CL, requiring additional testing for clarity.
New York Approved
Methodology
NGS
Biomarkers
LOINC Codes
- 105594-6 - Ovarian, fallo & perit multi anl Tiss
- 82939-0 - Genetic variant details Bld/T
- 69047-9 - Geneticist review
- 48767-8 - Annotation comment Imp
- 31208-2 - Specimen source
- 80398-1 - Unique ID Current sample
- 85069-3 - Lab test method
- 62364-5 - Test performance info Spec
- 18771-6 - Provider signing name
Result Turnaround Time
12-20 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Submit a formalin-fixed, paraffin-embedded tissue block with acceptable tumor tissue or slides with adequate tumor content and nuclei.
Causes for Rejection
Improper tissue treatment such as decalcification may cause assay failure.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |