Measles Virus, Molecular Detection, PCR, Random, Urine
Use
This test is useful for identifying measles infection using random urine specimens. Measles virus is a single-stranded, negative-sense RNA paramyxovirus belonging to the genus Morbillivirus that causes acute respiratory illness. Laboratory confirmation of measles cases can be achieved through the molecular detection of measles virus RNA, providing increased sensitivity and specificity compared to serologic testing when specimens are collected early after rash onset.
Special Instructions
This polymerase chain reaction (PCR) test should be ordered for individuals with suspected measles infection, displaying symptoms such as rash, cough, fever, and conjunctivitis 6 to 14 days after rash onset. The test is not recommended for patients 0 to 5 days after rash onset, where throat swab PCR is preferred.
Limitations
A negative test result does not rule out infection with measles virus. It is crucial to use test results in conjunction with clinical findings and serologic test results for accurate diagnosis. False-negative results may arise from improper sample collection or viral variants. Additionally, samples that are frozen, heat inactivated, or containing preservatives will be rejected. The potential for false-negative results exists due to improper sample collection or viral variants.
New York Approved
Methodology
PCR-based (RT-PCR)
Biomarkers
LOINC Codes
- 86577-4
- 86577-4
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
1 mL
Minimum Volume
0.3 mL
Container
Sterile tube
Collection Instructions
Collect a random urine specimen during the 6-to-14-day period after rash onset in a sterile urine tube. No preservative.
Storage Instructions
Specimens must be shipped at refrigerated temperature.
Causes for Rejection
Samples that have been heat inactivated or contain preservatives will be rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 7 days |