Merkel CC (MCPyV) Immunostain, Technical Component Only
Use
Identification of Merkel cell polyomavirus infected cells. MCPyV infections are common and typically benign, but in rare cases, they lead to Merkel cell carcinoma (MCC) due to the expression of MCPyV large T-antigen. MCPyV-positive MCC exhibits less aggressive behavior than MCPyV-negative MCC.
Special Instructions
Not provided.
Limitations
This test does not include pathologist interpretation, only technical performance of the stain. Interpretation should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist. The age of paraffin sections can affect immunoreactivity, and best practice is for paraffin sections to be cut within 6 weeks. Environmental factors may alter slide staining, and unsuitable slides can result in inconsistent staining.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Merkel cell polyomavirus large T-antigen
Protein
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Causes for Rejection
Wet/frozen tissue, Cytology smears, Nonformalin fixed tissue, Nonparaffin embedded tissue, Noncharged slides, ProbeOn slides, Snowcoat slides
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |
| Refrigerated | Refrigerated |