MET (7q31), FISH, Tissue
Use
Providing prognostic information and guiding treatment, primarily for patients with lung, gastric, and colorectal tumors, as well as other tumor types. MET amplification is associated with disease progression and has been reported in several types of cancer, including colorectal, gastric, and gastroesophageal adenocarcinoma. It is a mechanism for acquired resistance to EGFR-TKI therapies.
Special Instructions
A pathology report is required for testing to be performed. Appropriate tests may be added at the pathologist's discretion, incurring additional charges. This test does not include a pathology consultation, which must be ordered separately if needed. Multiple gene panels are available for oncology; please refer to the Hematology, Oncology, and Hereditary Test Selection Guide.
Limitations
This test is not FDA approved and serves as an adjunct to existing clinical and pathologic information. Fresh tissue is not acceptable, and fixatives other than formalin may not be successful. The FISH assay does not rule out other chromosomal abnormalities, and paraffin-embedded tissues that have been decalcified have a lower success rate for FISH analysis. If no cells are present for analysis or sufficient tumor tissue is unavailable, testing may be canceled.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 90926-7
- 50397-9
- 69965-2
- 62356-1
- 42349-1
- 31208-2
- 80398-1
- 85069-3
- 48767-8
- 62364-5
- 18771-6
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Submit a formalin-fixed, paraffin-embedded tumor tissue block. Provide fixation method used. Paraffin-embedded specimens can be from any anatomic location. Decalcified paraffin-embedded specimens will have testing attempted, but success rate is approximately 50%.
Causes for Rejection
Fresh tissue
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |