Methadone Confirmation, Random, Urine
Use
The Methadone Confirmation test is used for monitoring compliance of methadone treatment in patients undergoing therapy for analgesia or drug rehabilitation. Methadone is a synthetic opioid that binds to opioid receptors but does not produce euphoria and has fewer withdrawal symptoms compared to opiates. Measuring methadone and its primary metabolite, EDDP, in urine helps in assessing compliance with therapy and in detecting possible adulteration of urine samples through spiking.
Special Instructions
Not provided.
Limitations
Urine pH can affect methadone detection; thus, EDDP levels, which are less influenced by urine pH, are preferable for compliance assessment. Methadone urine concentrations do not correlate well with serum levels or the administered dose. The test cannot identify the causative factors for variations in methadone levels, such as individual metabolic differences or drug interactions.
New York Approved
Methodology
Mass Spectrometry (GC-MS)
Biomarkers
2-Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidine (EDDP)
AnalyteMethadone
Analyte
LOINC Codes
- 104626-7 - Methadone Confirmatory pnl Ur
- 104627-5 - EDDP Ur Ql GC-MS
- 104628-3 - Methadone Ur GC-MS-mCnc
- 69050-3 - Toxicologist review
- 77202-0 - Laboratory comment Report
Result Turnaround Time
3-7 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
10 mL
Minimum Volume
2.5 mL
Container
Plastic, 10-mL urine tube
Collection Instructions
Collect a random urine specimen. No preservative.
Causes for Rejection
None specified; gross hemolysis and gross icterus are acceptable.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 28 days |
| Frozen | 28 days |