Methylphenidate, Serum
Use
The Methylphenidate, Serum test is used for determining the serum concentration of methylphenidate (commonly known as Ritalin). This test is relevant for monitoring therapeutic drug levels, assessing compliance, and evaluating potential toxicity. It is particularly useful in individuals prescribed methylphenidate for attention-deficit hyperactivity disorder (ADHD) or narcolepsy, allowing healthcare providers to ensure appropriate dosing and therapeutic efficacy, as well as to identify any signs of overmedication or potential drug interactions.
Special Instructions
Submit only one of the following specimens: plasma drawn in a sodium heparin tube or serum drawn in a plain red-top tube. Plasma gel tube or serum gel tube is not acceptable. Specimens should be frozen immediately and sent on dry ice. Clearly label the specimen type submitted for testing.
Limitations
The test is limited by the sample collection process; improper handling or incorrect specimen type like the use of gel tubes, which are not acceptable, can result in test rejection. Additionally, while the test provides quantitative methylphenidate levels, it does not provide qualitative insights into patient adherence or differentiate between the various methylphenidate formulations and metabolites. Interferences and cross-reactivity with other substances taken by the patient should be considered.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 3807-5
- 3807-5
Result Turnaround Time
5-13 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
2 mL
Minimum Volume
0.5 mL
Container
Sodium heparin tube
Collection Instructions
Draw blood in a green-top (sodium heparin) tube, spin down and freeze immediately.
Storage Instructions
Send frozen on dry ice.
Causes for Rejection
Hemolysis, lipemia, icterus, other conditions affecting the specimen quality.
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | 180 days |