Use

This test is useful for evaluating tumor tissue to identify patients at high risk for having hereditary nonpolyposis colorectal cancer, also known as Lynch syndrome, as well as those at risk for hereditary endometrial carcinoma. Lynch syndrome is an autosomal dominant hereditary cancer syndrome associated with germline variants in mismatch repair genes, including MLH1. This immunohistochemistry test helps to identify tumors with defective DNA mismatch repair and is instrumental in identifying the gene responsible for the anomaly within the tumor.