Use

Hereditary erythrocytosis is a condition characterized by increased red blood cell (RBC) mass, which can be primary, due to intrinsic bone marrow defects, or secondary, related to increased serum erythropoietin levels. Secondary causes include chronic diseases like lung disease and heart conditions, and environmental factors like high-altitude living. When these common causes are ruled out, a heritable cause involving hemoglobin or erythrocyte regulatory mechanisms might be considered. Hereditary erythrocytosis can be inherited in an autosomal dominant or recessive manner and involves variations in specific genes including those related to hemoglobin, oxygen sensing, and erythropoietin pathways.