Use

This test aids in the diagnosis and monitoring of chronic myelomonocytic leukemia (CMML), a myelodysplastic syndrome/myeloproliferative neoplasm overlap syndrome. It is characterized by peripheral blood monocytosis with an absolute monocyte count ≥1.0 x 10⁹/L and ≥10% of the total white blood cell count persisting for 3 months or longer. Monocytes are classified into classical (MO1), intermediate (MO2), and non-classical (MO3) subsets. A characteristic increase in classical monocytes (≥94%) has been demonstrated in CMML patients, distinguishing them from other causes of monocytosis with over 90% sensitivity and specificity. This panel analyzes the repartition of monocytes to provide a semiquantitative value for the MO1 compartment, aiding in differential diagnosis and monitoring of CMML.