Mucin 2, Immunostain, Technical Component Only
Use
Mucin 2 (MUC2) is a 520 kDa glycoprotein belonging to the family of secretory mucins. MUC2 is expressed in the cytoplasm of goblet cells. An immunopanel consisting of MUC1, MUC2, MUC5AC, and MUC6 is useful in subtyping intraductal papillary mucinous neoplasms. This test aids in subtyping intraductal papillary mucinous neoplasms, providing valuable insight into their classification.
Special Instructions
This test includes only the technical performance of the stain; no pathologist interpretation is provided. Technical component only stains should not be ordered with PATHC / Pathology Consultation. If ordered with PATHC, the technical component stains will be canceled.
Limitations
Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen dependent. Best practice is for paraffin sections to be cut within 6 weeks. The charge of glass slides can be affected by environmental factors and subsequently may alter slide staining. Sending unsuitable glass slides can result in inconsistent staining due to poor slide surface chemistry.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Collection Instructions
Attach the green 'Attention Pathology' address label (T498) and the pink Immunostain Technical Only label included in the kit to the outside of the transport container. Preferred specimen is Formalin-fixed, paraffin-embedded tissue block or 2 Unstained, positively charged glass slides (25- x 75- x 1-mm) per test ordered.
Storage Instructions
Best practices for storage of positively charged slides: Minimize time slides are stored after being unpackaged, limit exposure to high humidity and heat, minimize exposure to plastics.
Causes for Rejection
Wet/frozen tissue, Cytology smears, Nonformalin fixed tissue, Nonparaffin embedded tissue, Noncharged slides, ProbeOn slides, Snowcoat slides
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |
| Refrigerated | Refrigerated |