Mucin 4, Immunostain, Technical Component Only
Use
Mucin 4 (MUC4) is a large membrane-anchored glycoprotein belonging to the mucin family, which plays important roles in the protection of epithelial cells and epithelial renewal and differentiation. It is expressed in the cytoplasm and membrane of respiratory, gastrointestinal, cervical, and prostatic epithelial cells. Its overexpression is observed in many carcinomas, and it aids in differentiating sarcomatoid carcinoma (often expressed) from sarcomatoid mesothelioma (usually negative).
Special Instructions
This test includes only the technical performance of the stain; no pathologist interpretation is provided. Pathology Consultation (PATHC) must be ordered separately for interpretation as IHC stains performed as part of PATHC will be at the pathologist's discretion.
Limitations
The test is performed only on formalin-fixed, paraffin-embedded tissue, or on positively-charged glass slides. Nonformalin fixed or nonparaffin embedded tissues and certain types of slides will be rejected. Additionally, age and handling of paraffin sections can affect immunoreactivity. Best practice recommends cutting paraffin sections within 6 weeks to maintain antigen stability.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Storage Instructions
Best practices for storage include minimizing the time slides are stored after being unpackaged, limiting exposure to high humidity and heat, and minimizing exposure to plastics.
Causes for Rejection
Wet/frozen tissue, cytology smears, nonformalin fixed tissue, nonparaffin embedded tissue, noncharged slides, ProbeOn slides, Snowcoat slides