Mycoplasma pneumoniae Antibodies, IgG and IgM, Serum

Casandra

Casandra Test Code MC90699Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID MYCOCPT Code 86738

Mycoplasma pneumoniae Antibodies, IgG and IgM, Serum

Clinical Use

Use

Screening for recent or past exposure to Mycoplasma pneumoniae. The test helps in identifying IgG and IgM antibodies to M pneumoniae in serum, which is used to provide exposure information. It should not be used as a screening procedure for the general population, as detection of IgM or IgG class antibodies provides exposure information rather than confirmation of active infection. The presence of antibodies provides information about prior exposure, and possibly disease.

Special Instructions

If the Mycoplasma pneumoniae IgM result is reactive or equivocal, a confirmatory test using an indirect immunofluorescence assay will be performed at an additional charge. Ensure samples are centrifuged and aliquoted into plastic vials before submission. Use the Infectious Disease Serology Test Request form if not ordering electronically.

Limitations

Serology-based assays for M pneumoniae have several drawbacks. The development of IgM antibodies takes approximately 1 week, and the IgM may vary in adults or be decreased in immunosuppressed individuals. The test results should be interpreted with clinical evaluation and other diagnostic results. Cross-reactivity with organisms like Mycoplasma hominis and Ureaplasma species has not been thoroughly studied, potentially leading to inaccurate diagnoses especially if cross-reactive organisms are present. Test should not be used solely for infection diagnosis without other clinical correlation.

Test Details

New York Approved