Myeloid Sarcoma, FISH, Tissue
Use
This test is useful for detecting recurrent chromosome abnormalities associated with acute myeloid leukemia (AML) and myeloid sarcomas in paraffin-embedded tissue specimens. It aids in monitoring the response to therapy by tracking known chromosome abnormalities. Detection of chromosome abnormalities such as t(8;21), t(9;22), t(15;17), inv(16), and rearrangements of the KMT2A gene can provide relevant prognostic information as these abnormalities are associated with the extramedullary presentation of AML or may indicate relapse.
Special Instructions
Not provided.
Limitations
The test is not approved by the FDA and should be used as an adjunct to existing clinical and pathologic information. It does not detect other chromosome abnormalities outside of the probed regions. Fixatives other than formalin may be less successful, and paraffin-embedded tissues that have been decalcified have a 50% success rate for FISH analysis. Insufficient tumor tissue may lead to cancellation of the test.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 50397-9 - Mol dx interp Bld/T Ql
- 69965-2 - Clinical cytogeneticist review
- 93356-4 - Cells w cytogenetic abnl Bld/T
- 62356-1 - Chrom analy result (ISCN)
- 42349-1
- 31208-2 - Specimen source
- 80398-1 - Unique ID Current sample
- 85069-3 - Lab test method
- 18771-6 - Provider signing name
- 48767-8 - Annotation comment Imp
- 62364-5 - Test performance info Spec
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Tissue block or slides
Collection Instructions
Submit a formalin-fixed, paraffin-embedded tumor tissue block or 1 hematoxylin and eosin-stained slide with 2 unstained slides per probe set. For a complete panel, provide 10 unstained slides. Note fixation method used.
Storage Instructions
Ambient or refrigerated transport conditions are acceptable.
Causes for Rejection
Non-formalin fixed specimens may not be suitable for testing.