Myeloma, High Risk with Reflex Probes, Diagnostic FISH Evaluation, Fixed Cell Pellet

Casandra

Casandra Test Code MC40678Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID MFCDFCPT Codes 88271, 88275, 88291

Myeloma, High Risk with Reflex Probes, Diagnostic FISH Evaluation, Fixed Cell Pellet

Clinical Use

Use

This test is useful for detecting recurrent high-risk chromosome abnormalities associated with multiple myeloma and other plasma cell proliferative disorders when fresh bone marrow is unavailable. It helps in evaluating specimens where bone marrow is past 96 hours from collection. It should not be used to track the progression of the disease but is aimed at assessing diagnostic bone marrow specimens, ensuring that the marrow demonstrates a significant percentage of involvement by a plasma cell proliferative disorder for best results.

Special Instructions

A list of probes requested for analysis is required if specific probes are necessary or if the patient is being tracked for known abnormalities. Probes available for this test are listed in the Testing Algorithm section. A reason for testing must be provided. If fresh bone marrow is received within 96 hours of collection, this test will be canceled and reordered as PCPDS. Ship samples via express mail or equivalent if not on courier service.

Limitations

This test is not approved by the US Food and Drug Administration and should be used as an adjunct to existing clinical and pathologic information. The absence of an abnormal clone does not rule out the presence of a plasma cell clone or another neoplastic disorder. If no FISH signals are observed post-hybridization, the case will be released indicating a lack of FISH results.

Test Details

New York Approved