Myeloma, High Risk with Reflex Probes, Diagnostic FISH Evaluation, Fixed Cell Pellet
Use
This test is useful for detecting recurrent high-risk chromosome abnormalities associated with multiple myeloma and other plasma cell proliferative disorders when fresh bone marrow is unavailable. It helps in evaluating specimens where bone marrow is past 96 hours from collection. It should not be used to track the progression of the disease but is aimed at assessing diagnostic bone marrow specimens, ensuring that the marrow demonstrates a significant percentage of involvement by a plasma cell proliferative disorder for best results.
Special Instructions
Not provided.
Limitations
This test is not approved by the US Food and Drug Administration and should be used as an adjunct to existing clinical and pathologic information. The absence of an abnormal clone does not rule out the presence of a plasma cell clone or another neoplastic disorder. If no FISH signals are observed post-hybridization, the case will be released indicating a lack of FISH results.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- In Process
- 50397-9 - Mol dx interp Bld/T Ql
- 69965-2 - Clinical cytogeneticist review
- 93356-4 - Cells w cytogenetic abnl Bld/T
- 62356-1 - Chrom analy result (ISCN)
- 42349-1
- 31208-2 - Specimen source
- 85069-3 - Lab test method
- 48767-8 - Annotation comment Imp
- 62364-5 - Test performance info Spec
- 18771-6 - Provider signing name
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
1 Fixed cell pellet
Minimum Volume
Not provided
Container
Sterile container
Collection Instructions
Place specimen in a sterile container with a 3:1 methanol:glacial acetic acid (or similar) fixative.
Causes for Rejection
Fresh tissue
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |