Myogenin Immunostain, Technical Component Only
Use
Myogenin is a marker of skeletal muscle differentiation. It is a member of a family of myogenic regulatory genes crucial for muscle development, including MyoD, myf5, and MRF4. These genes encode transcription factors found in the majority of rhabdomyosarcomas and Wilms tumors, but absent in Ewing sarcoma and mature skeletal muscle. This test is used to identify skeletal muscle differentiation in tissues through immunohistochemistry.
Special Instructions
Not provided.
Limitations
The test does not include pathologist interpretation. Positive and negative controls are verified for appropriate immunoreactivity. Interpretation should be contextualized with the patient's clinical history. The charge of slides and age of paraffin sections can affect immunoreactivity, requiring specific conditions to maintain stability. Paraffin sections should be cut within 6 weeks for optimal results.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Myogenin
Protein
LOINC Codes
- Order only; no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Storage Instructions
Ambient (preferred), Refrigerated
Causes for Rejection
Wet/frozen tissue, Cytology smears, Nonformalin fixed tissue, Nonparaffin embedded tissue, Noncharged slides, ProbeOn slides, Snowcoat slides