Napsin A Immunostain, Technical Component Only
Use
Napsin A is an aspartic proteinase involved in the proteolytic processing of surfactant precursors in the normal alveolar epithelium. In normal tissues, napsin A is expressed in the cytoplasm of alveolar macrophages, type II pneumocytes, pancreatic ducts and acini, and in renal tubules. Napsin A has clinical utility for the identification of primary lung adenocarcinomas and is also positive in a subset of thyroid and renal cell carcinomas (especially papillary type).
Special Instructions
Not provided.
Limitations
This test does not include pathologist interpretation, only the technical performance of the stain. For a full diagnostic evaluation, order PATHC / Pathology Consultation. The age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary among published literature and are antigen-dependent. Proper storage of positively charged slides is critical to avoid alterations in slide staining.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- NAPSN
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Collection Instructions
Attach the green 'Attention Pathology' address label (T498) and the pink Immunostain Technical Only label to the container. Formalin-fixed, paraffin-embedded tissue block or 2 unstained, positively charged glass slides (25- x 75- x 1-mm); sections 4-microns thick.
Storage Instructions
Ambient (preferred) or Refrigerated
Causes for Rejection
Wet/frozen tissue, cytology smears, nonformalin fixed tissue, nonparaffin embedded tissue, noncharged slides, ProbeOn slides, Snowcoat slides