Neurochondrin Antibody, Cell-Binding Assay, Serum
Use
This test is useful for evaluating neurochondrin-IgG by cell-binding assay using serum from patients presenting with cerebellar and brainstem syndrome. Neurochondrin is a neuronal target antigen in autoimmune cerebellar degeneration, and patients may respond to long-term immunosuppressive treatment. The test may support the diagnosis of central nervous system autoimmunity, and neurological stabilization or improvement can occur with immune therapy.
Special Instructions
The test is only orderable as a reflex following an indirect immunofluorescence (IFA) pattern that suggests neurochondrin. Additional charges apply for the reflex and neurochondrin antibody IFA titer.
Limitations
A negative result does not exclude neurological autoimmunity or cancer. While a positive result supports a diagnosis, a paraneoplastic basis should be considered though cancers are generally not detected. Proper specimen collection and handling are critical to avoid diagnostic confusion.
New York Approved
Methodology
Cell-based / Cytometry
Biomarkers
LOINC Codes
- 101450-5
- 101450-5
Result Turnaround Time
5-10 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Only orderable as a reflex. Refer to initial order tests for more information.
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 28 days |
| Frozen | 28 days |