Neurochondrin Antibody, Cell-Binding Assay, Serum
Use
This test is useful for evaluating neurochondrin-IgG by cell-binding assay using serum from patients presenting with cerebellar and brainstem syndrome. Neurochondrin is a neuronal target antigen in autoimmune cerebellar degeneration, and patients may respond to long-term immunosuppressive treatment. The test may support the diagnosis of central nervous system autoimmunity, and neurological stabilization or improvement can occur with immune therapy.
Special Instructions
Not provided.
Limitations
A negative result does not exclude neurological autoimmunity or cancer. While a positive result supports a diagnosis, a paraneoplastic basis should be considered though cancers are generally not detected. Proper specimen collection and handling are critical to avoid diagnostic confusion.
New York Approved
Methodology
Cell-based / Cytometry
Biomarkers
Neurochondrin-IgG
Protein
LOINC Codes
- 101450-5 - Neurochondrin Ab SerPl Ql CBA IFA
- 101450-5 - Neurochondrin Ab SerPl Ql CBA IFA
Result Turnaround Time
5-10 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Only orderable as a reflex. Refer to initial order tests for more information.
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 28 days |
| Frozen | 28 days |