Neuroimmunology Antibody Follow-up, Serum
Use
Monitoring patients who have previously tested positive for one or more antibodies within the past 5 years in a Mayo Clinic Laboratories serum evaluation. Paraneoplastic autoimmune neurological disorders reflect a patient's humoral and cellular immune responses to cancer. Autoantibodies specific for onconeural proteins found in the plasma membrane, cytoplasm, and nucleus of neurons or muscle serve as serological markers of paraneoplastic autoimmunity.
Special Instructions
This test is only appropriate as a follow-up in patients who have a previous positive serum test result. This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. Specimens will be screened for radioactivity prior to analysis.
Limitations
The specific waiting period before specimen collection will depend on the isotope administered, the dose given, and the clearance rate in the individual patient. Radioactive specimens received in the laboratory will be held 1 week and assayed if sufficiently decayed or canceled if radioactivity remains.
New York Approved
Methodology
Other
Biomarkers
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
4 mL
Minimum Volume
2 mL
Container
Plastic vial
Collection Instructions
Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 28 days |
| Frozen | 28 days |