Neuromyelitis Optica (NMO)/Aquaporin-4-IgG Fluorescence-Activated Cell Sorting (FACS) Assay, Serum
Use
This test is utilized for the diagnosis of a neuromyelitis optica spectrum disorder (NMOSD), autoimmune AQP4 channelopathy, and neuromyelitis optica (NMO). It is also instrumental in distinguishing NMOSD from multiple sclerosis early in the disease course, enabling early initiation and maintenance of appropriate immunosuppressive therapy.
Special Instructions
Ensure proper specimen collection by centrifuging and aliquoting serum into a plastic vial. Refer to the forms section for required documentation if not ordering electronically.
Limitations
AQP4-IgG antibodies may drop below detectable levels in settings of therapies for acute attacks (e.g., IV methylprednisolone or plasmapheresis) or attack prevention (e.g., immunosuppressants). Additionally, the assay's sensitivity is contingent upon proper specimen handling and adherence to testing protocols.
New York Approved
Methodology
Cell-based / Cytometry (Flow Cytometry)
Biomarkers
LOINC Codes
- 43638-6
- 43638-6
Result Turnaround Time
5-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL
Minimum Volume
2 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis: OK, Gross lipemia: OK, Gross icterus: OK
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 28 days |
| Frozen | 28 days |