Nuclear Magnetic Resonance Lipoprotein Profile, Serum
Use
The Nuclear Magnetic Resonance Lipoprotein Profile is useful for the assessment and management of a patient's risk for atherosclerotic cardiovascular disease (ASCVD). This test helps identify residual risk that may be present in some patients receiving cholesterol-targeting treatment by measuring lipoprotein particles through Nuclear Magnetic Resonance (NMR). LDL-P concentration is positively associated with increased risk of ASCVD, and is considered a more accurate reflection of risk compared to LDL cholesterol values alone. HDL-P concentration inversely correlates with ASCVD risk, even amongst those on cholesterol-lowering medications.
Special Instructions
Not provided.
Limitations
The test may be hindered by failure to follow specimen collection requirements, which could prevent measurable results. Additionally, gross hemolysis, lipemia, or icterus may cause specimen rejection. Moreover, reference values are not established for patients younger than 18 years of age, which could limit applicability.
New York Approved
Methodology
Other
Biomarkers
HDL Particles
AnalyteLDL Cholesterol (NMR)
AnalyteLDL Particles
Analyte
LOINC Codes
- 92722-8 - Lipoprotein subparticle profile Pnl Ser
- 54434-6 - LDL SerPl-sCnc
- 49748-7 - HDL SerPl-sCnc
- 2089-1 - LDLc SerPl-mCnc
Result Turnaround Time
2-7 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1.5 mL
Minimum Volume
1 mL
Container
Plastic vial
Collection Instructions
Allow isopropyl alcohol from phlebotomy site prep to dry thoroughly before venipuncture. Centrifuge and aliquot serum into a plastic vial.
Patient Preparation
Fasting for 12 hours is required; evening meal eaten by 6 p.m. with no fatty foods, no alcohol for 24 hours before collection.
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 8 hours |
| Refrigerated | 7 days |
| Frozen | 14 days |