Olanzapine (Zyprexa)
Use
Olanzapine, marketed under the brand name Zyprexa, is an antipsychotic medication primarily used to treat schizophrenia and bipolar disorder. The test measures plasma concentrations of olanzapine to evaluate therapeutic levels and to monitor adherence and potential toxicity. Testing assists in the management of patients by ensuring that they maintain therapeutic drug levels for effective treatment outcomes.
Special Instructions
The test requires specific specimen handling, including drawing blood into designated tubes (green-top sodium heparin or plain red-top), with precise processing to refrigerate and transport within specified stability conditions. Coordination with the laboratory for proper temperature management during transportation is important to ensure sample integrity.
Limitations
The test does not provide sensitivity to predict therapeutic outcomes beyond measuring steady-state concentrations. Plasma levels reaching 9.0 ng/mL are associated with therapeutic effects, yet levels exceeding this range without clinical symptoms do not diagnose toxicity. Additionally, potential interference by other medications or conditions affecting metabolism may influence test outcomes.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 12389-3
- 12389-3
Result Turnaround Time
7-11 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
2 mL
Minimum Volume
0.50 mL
Container
Plastic vial
Collection Instructions
Draw blood in a green-top (sodium heparin) tube. Spin down and send plasma refrigerated.
Storage Instructions
Refrigerated (preferred) for up to 14 days or frozen up to 180 days.
Causes for Rejection
Not applicable for hemolysis, lipemia, icterus.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 14 days |
| Frozen | 180 days |