p62 Immunostain, Technical Component Only
Use
This test is useful for aiding in the diagnosis of argyrophilic grain disease (AGD), a common late-onset dementia. AGD is characterized by the presence of argyrophilic grains and coiled bodies and is frequently found in patients diagnosed with amnestic-type mild cognitive impairment. The immunohistochemical detection of ubiquitin-binding protein p62 is sensitive and reproducible, helping to identify grain pathology in AGD effectively.
Special Instructions
Not provided.
Limitations
The test does not include pathologist interpretation, only the technical performance of the stain. If interpretation is required, a PATHC / Pathology Consultation should be ordered for a complete diagnostic evaluation or second opinion. Age of the paraffin section can impact immunoreactivity as stability varies widely and is antigen dependent. Specimen integrity can be affected by environmental factors, especially the charge of glass slides, which may alter staining quality if exposed to improper conditions.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
p62
Protein
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Collection Instructions
The specimen should be formalin-fixed, paraffin-embedded tissue block or 2 unstained, positively charged glass slides (25- x 75- x 1-mm) per test ordered, sections 4-microns thick. Apply appropriate labels for 'Attention Pathology' and 'Immunostain Technical Only'.
Causes for Rejection
Wet/frozen tissue, Cytology smears, Nonformalin fixed tissue, Nonparaffin embedded tissue, Noncharged slides, ProbeOn slides, Snowcoat slides
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |
| Refrigerated | Refrigerated |