Paliperidone, Serum
Use
Paliperidone is an atypical antipsychotic medication and the principal active metabolite of the drug risperidone. It is utilized primarily in the treatment of schizophrenia and schizoaffective disorders due to its ability to modify the balance of neurotransmitters in the brain. Therapeutic drug monitoring of paliperidone concentration in serum is important for optimizing dosage, ensuring compliance, and avoiding toxicity, especially when prescribing extended-release formulations or depot injections. Dosage adjustments based on serum levels can help in achieving desired clinical outcomes while minimizing side effects.
Special Instructions
Not provided.
Limitations
This test was developed and its performance characteristics determined by NMS Labs. It has not been cleared or approved by the U.S. Food and Drug Administration. The accuracy of the paliperidone serum concentration can be affected by improper handling of the specimen, such as using serum separator tubes. Furthermore, the test may not detect extremely low levels of the drug, and the presence of other antipsychotics or their metabolites can potentially interfere with the results. Interpretation of serum concentrations should be considered in the context of the patient's clinical condition and history of dosing.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
Paliperidone
Analyte
LOINC Codes
- 9383-1 - 9OH-risperidone SerPl-mCnc
- 9383-1 - 9OH-risperidone SerPl-mCnc
Result Turnaround Time
8-10 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Plastic vial
Collection Instructions
Draw blood in a plain, red-top tube(s). (Serum gel tube is not acceptable.) Spin down and send 1 mL of serum refrigerate in a preservative-free plastic vial.
Causes for Rejection
Polymer gel separation tube (SST or PST)
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |