Pear, IgE, Serum
Use
The Pear, IgE test is useful for establishing a diagnosis of an allergy to pears by detecting IgE antibodies in the serum. It identifies pear as the allergen responsible for allergic reactions and confirms sensitization before immunotherapy. This test can also help investigate the specificity of allergic reactions in cases involving insect venom allergens, drugs, or chemical allergens. Understanding the allergic response is crucial in managing related allergic diseases, which manifest through the release of proinflammatory mediators like histamine from IgE-sensitized cells upon allergen interaction.
Special Instructions
Not useful for assessing residual clinical sensitivity following immunotherapy or when the medical management does not require identifying allergen specificity. The test employs a Fluorescence Enzyme Immunoassay (FEIA) methodology and is approved for use in New York State.
Limitations
False positives may occur in individuals with markedly elevated serum IgE levels (>2500 kU/L) due to nonspecific binding. It's important to interpret results in the patient's specific clinical context, especially because some individuals might show measurable IgE levels to clinically insignificant sensitivities. Specimen rejection criteria include gross hemolysis and gross lipemia, and incorrect specimen handling can lead to diagnostic confusion.
New York Approved
Methodology
Immunoassay (FEIA)
Biomarkers
LOINC Codes
- 6207-5
- 6207-5
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL for every 5 allergens requested
Minimum Volume
Not provided
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis, Gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 14 days |
| Frozen | 90 days |