Phosphatidylserine/Prothrombin Antibody, IgG, Serum
Use
Phosphatidylserine/prothrombin antibody, IgG, serum tests are essential for detecting IgG antibodies against the phosphatidylserine/prothrombin complex in patients strongly suspected of having antiphospholipid syndrome (APS) who are negative for the standard APS criteria laboratory tests. These antibodies may be useful for evaluating patients with prior positive lupus anticoagulant results, especially those on direct oral anticoagulant therapy, and serve as a risk marker for thrombosis in antiphospholipid antibody carriers.
Special Instructions
Phosphatidylserine/prothrombin antibodies are part of a second-tier workup. Cardiolipin and beta-2 glycoprotein testing are first-tier options. The test is performed on Wednesdays, and results are available in 2 to 8 days. Specimens are retained for 14 days after testing.
Limitations
A diagnosis of antiphospholipid syndrome (APS) should not be based merely on the presence of anti-phosphatidylserine/prothrombin antibodies, as they are not yet included in the official APS classification criteria. The test results must be interpreted within the appropriate clinical context. A negative result does not exclude APS as other phospholipid and/or protein antibodies may also be involved.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 85359-8
- 85359-8
Result Turnaround Time
2-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.4 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial. Preferred: Serum gel; Acceptable: Red top.
Causes for Rejection
Gross hemolysis, gross lipemia, heat treated specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 21 days |
| Frozen | 21 days |