Plasma Cell Assessment, Blood
Use
This test is useful for detecting peripheral blood involvement by plasma cell proliferative disorders. It helps to establish the diagnosis and determine the prognosis for plasma cell proliferative disorders. Identifying plasma cell immunoglobulin light chain restriction is crucial in assessing plasma cell clonality and establishing a diagnosis. Higher peripheral blood involvement usually indicates more aggressive disease types, serving as an adverse prognostic indicator.
Special Instructions
Not provided.
Limitations
Traditional flow cytometry for assessing plasma cell clonality has limitations, including insensitivity and underestimation of clonal plasma cells due to instrument and antibody reagent limitations, as well as intraclonal phenotypic heterogeneity. These limitations complicate accurate detection and enumeration of clonal plasma cells.
New York Approved
Methodology
Cell-based / Cytometry (Flow Cytometry)
Biomarkers
LOINC Codes
- 86900-8 - Monotypic plasma cells Bld FC
- 86900-8 - Monotypic plasma cells Bld FC
- 19099-1 - Events Counted Spec
- 69052-9 - Flow cytometry specialist review
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
10 mL
Minimum Volume
4 mL
Container
Preferred: Green top (sodium heparin); Acceptable: Lavender top (EDTA)
Collection Instructions
Do not centrifuge. Send whole blood specimen in original tube. Do not aliquot.
Causes for Rejection
Gross hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 72 hours |