Plasma Cell Proliferative Disorder, FISH, Tissue
Use
This test supports the diagnosis of plasmacytoma or myeloma when coordinated with a surgical pathology consultation. It detects recurrent common chromosome abnormalities in patients with a plasmacytoma or myeloma in paraffin-embedded tissue specimens. This provides critical genetic information that aids in the clinical management and prognostication of plasma cell neoplasms.
Special Instructions
A minimum of 35% plasma cell involvement is required for a successful paraffin plasma cell FISH evaluation. Additionally, a pathology report is required for testing to be performed. The report should include the patient's name, block number, date of collection, and tissue source. If no pathology report is provided, testing may be compromised or delayed.
Limitations
This test is not FDA-approved and should be used as an adjunct to existing clinical and pathologic information. Non-formalin fixed specimens and decalcified paraffin-embedded tissues may not yield successful FISH analysis. FISH analysis will not be performed if sufficient plasma cells are absent in the specimen. If less than 35% plasma cell involvement is found in a bone marrow specimen, testing will be canceled.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 50397-9
- 69965-2
- 93356-4
- 62356-1
- 42349-1
- 31208-2
- 80398-1
- 85069-3
- 48767-8
- 18771-6
- 62364-5
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Slides: 1 Hematoxylin and eosin stained and 7 unstained
Collection Instructions
Submit a formalin-fixed, paraffin-embedded tumor tissue block or 10 consecutive unstained, positively charged, unbaked slides.
Causes for Rejection
Specimens evaluated unsuitable for testing at Mayo Clinic Laboratories.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |