Plasma Cell Proliferative Disorder, FISH, Tissue
Use
This test supports the diagnosis of plasmacytoma or myeloma when coordinated with a surgical pathology consultation. It detects recurrent common chromosome abnormalities in patients with a plasmacytoma or myeloma in paraffin-embedded tissue specimens. This provides critical genetic information that aids in the clinical management and prognostication of plasma cell neoplasms.
Special Instructions
Not provided.
Limitations
This test is not FDA-approved and should be used as an adjunct to existing clinical and pathologic information. Non-formalin fixed specimens and decalcified paraffin-embedded tissues may not yield successful FISH analysis. FISH analysis will not be performed if sufficient plasma cells are absent in the specimen. If less than 35% plasma cell involvement is found in a bone marrow specimen, testing will be canceled.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 50397-9 - Mol dx interp Bld/T Ql
- 69965-2 - Clinical cytogeneticist review
- 93356-4 - Cells w cytogenetic abnl Bld/T
- 62356-1 - Chrom analy result (ISCN)
- 42349-1
- 31208-2 - Specimen source
- 80398-1 - Unique ID Current sample
- 85069-3 - Lab test method
- 48767-8 - Annotation comment Imp
- 18771-6 - Provider signing name
- 62364-5 - Test performance info Spec
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Slides: 1 Hematoxylin and eosin stained and 7 unstained
Collection Instructions
Submit a formalin-fixed, paraffin-embedded tumor tissue block or 10 consecutive unstained, positively charged, unbaked slides.
Causes for Rejection
Specimens evaluated unsuitable for testing at Mayo Clinic Laboratories.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |