Platelet Antibody Screen, Serum

Clinical Use

Use

Detecting alloantibodies to epitopes on platelet glycoproteins IIb/IIIa, Ib/Ix, Ia/IIa, IV and class I human leukocyte antigens to evaluate cases of immune mediated refractoriness to platelet transfusions, posttransfusion purpura, or neonatal alloimmune thrombocytopenia. Platelet alloantibodies are involved in several clinical situations such as immune mediated refractoriness to platelet transfusions due to antibodies to class I human leukocyte antigens and sometimes to antibodies specific to platelet antigens. It is also used in the evaluation of neonatal alloimmune thrombocytopenia and posttransfusion purpura, which are usually associated with platelet-specific antibodies.

Special Instructions

Not provided.

Limitations

This assay is intended for use as a screening assay. The results of this assay should not be used as the sole basis for clinical decision making. The reaction patterns produced should not be relied on solely to establish the identity of a platelet antibody. Positive or negative results obtained using this assay should be used in conjunction with clinical findings or other serological tests. Recent IVIg treatment may cause false positivity against certain glycoproteins. Some low-titer, low-avidity antibodies may not be detected. The presence of other human platelet antigen polymorphic variants has not been determined for the antigens captured in this kit. Antibodies to these systems may be reactive in this assay. Antibodies to low incidence class I human leukocyte antigens may not be detected using this product. This test has not been evaluated for the detection of autoantibodies to platelet antigens.

Test Details

FDA Approved