Postmortem Arrhythmia Gene Panel, Tissue
Use
This test provides a comprehensive postmortem genetic evaluation in cases of sudden death suspicious for cardiac arrhythmia. It helps identify disease-causing variants in the decedent, facilitating risk assessment and predictive testing of at-risk family members. The test targets 44 genes associated with hereditary cardiac arrhythmias and supports genetic counseling for these conditions.
Special Instructions
Not provided.
Limitations
Next-generation sequencing may not detect all genomic variants, especially in gene regions with homology, high GC content, or repetitive sequences. Large deletions-insertions and regions causing technical limitations may result in false negatives. Confirmation by Sanger sequencing is not performed. The test doesn't differentiate somatic from germline variants and doesn't detect low-level mosaicism. Target regions not meeting criteria will be noted. Detection of mitochondrial inheritance patterns is not included in this test.
New York Approved
Methodology
NGS (Targeted)
Biomarkers
LOINC Codes
- 62364-5 - Test performance info Spec
- 31208-2 - Specimen source
- 50397-9 - Mol dx interp Bld/T Ql
- 82939-0 - Genetic variant details Bld/T
- 69047-9 - Geneticist review
- 99622-3 - Patient resource info
- 48767-8 - Annotation comment Imp
- 85069-3 - Lab test method
- 18771-6 - Provider signing name
Result Turnaround Time
28-42 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Tissue block
Collection Instructions
Submit a formalin-fixed, paraffin-embedded tissue block.
Causes for Rejection
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |