Powassan Virus, IgM, Enzyme-Linked Immunosorbent Assay, Serum
Use
This test is used for the diagnosis of Powassan virus infection in patients. Powassan virus (POWV) is an emerging tick-borne virus that is transmitted by the same ticks that carry Lyme disease and other pathogens. It is a member of the flavivirus genus, which includes West Nile virus and Zika virus. About 66% of infections are asymptomatic, but a significant portion can lead to serious neurological manifestations, including encephalitis.
Special Instructions
This test should be used for patients with at least 7 days of symptoms consistent with Powassan virus infection and exposure history. Specimens positive for POWV may require confirmatory testing by a POWV neutralization assay. Contact local public health laboratories or CDC for confirmatory testing if necessary.
Limitations
The test should not be used for general population screening or as a 'test of cure.' False-negative results can occur in immunocompromised individuals or if the specimen is collected too soon after infection. False-positive results may arise in patients with prior or concurrent infections with other flaviviruses. Hemolytic, lipemic, and icteric specimens can lead to rejection.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 29855-4
- 29855-4
Result Turnaround Time
1-6 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.6 mL
Minimum Volume
0.5 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial. Preferred collection container is a serum gel tube, but a red top tube is also acceptable.
Causes for Rejection
Gross hemolysis, lipemia, icterus, and heat-inactivated specimens are cause for rejection.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 14 days |
| Frozen | 30 days |