Protein/Creatinine Ratio, Random, Urine
Use
The Protein/Creatinine Ratio, Random, Urine test is essential for evaluating renal disease and screening for monoclonal gammopathy. It helps in detecting increased protein levels in urine, which may indicate glomerular, tubular, or overflow proteinuria. Glomerular proteinuria results from defects in the filtration barrier, whereas tubular proteinuria is due to reabsorption failure. Overflow proteinuria is often linked to increased plasma protein levels. This test assists clinicians in assessing protein composition in urine, aiding diagnosis and management of the underlying conditions.
Special Instructions
Specimens should be collected before the administration of fluorescein or at least 24 hours afterwards. Use Sarstedt Aliquot Tube, 5 mL for specimen collection. Collect a random urine specimen with no preservative and invert well before taking the 4 mL aliquot. Ensure the aliquot tube is not overfilled beyond 4 mL.
Limitations
The interpretation of urinary protein levels may be confused by contamination with menstrual blood, prostatic secretions, or semen. Higher protein excretion in newborns during the first 3 days of life should be considered normal. Hemoglobin presence can falsely elevate protein concentration in urine. Additional assays like protein electrophoresis and immunofixation might be needed for comprehensive assessment and characterization of proteinuria.
FDA ApprovedNew York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 87434-7
- 2888-6
- 2161-8
- 2890-2
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
4 mL
Minimum Volume
1 mL
Container
Plastic vial
Collection Instructions
Collect a random urine specimen. No preservative. Invert well before taking 4 mL aliquot. Do not overfill aliquot tube, 4 mL at most.
Patient Preparation
Specimens should be collected before fluorescein is given or not collected until at least 24 hours later.
Causes for Rejection
All specimens will be evaluated for test suitability.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 14 days |
| Frozen | 30 days |