Protein, Total, 12 Hour, Urine
Use
The Protein, Total, 12 Hour, Urine test is clinically useful for the evaluation of renal disease, as well as screening for conditions such as monoclonal gammopathy, and postural (orthostatic) proteinuria. In certain clinical situations, like monitoring pregnant patients for preeclampsia, a 12-hour urine specimen can provide rapid insight into proteinuria states, allowing for quicker healthcare responses.
Special Instructions
A 12-hour urine collection is mandatory for this test, and proper instructions including not collecting specimens immediately after fluorescein administration must be adhered to, or 24-hour delay is required. Ensure correct labeling and handling during and after collection to avoid rejection. Any non-electronic orders require completion of the Renal Diagnostics Test Request form.
Limitations
Protein excretion variations can occur due to physiological or pathological conditions such as glomerular defects, tubular reabsorption issues, overflow proteinuria, or urinary tract conditions like inflammation or tumor. False positives may result from contamination with bodily secretions or vigorous exercise. Age-specific reference values below 18 years are not established, necessitating caution in pediatric environments.
FDA ApprovedNew York Approved
Methodology
Automated Analyzer (Clinical Chemistry)
Biomarkers
LOINC Codes
- 26801-1
- 26801-1
- 13362-9
- 13620-0
- 12842-1
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
4 mL
Minimum Volume
1 mL
Container
Plastic, 5 mL tube
Collection Instructions
Collect a 12-hour urine specimen before fluorescein administration or at least 24 hours post-dose. No preservatives allowed. Ensure mixture is inverted well before aliquot extraction, with no more than 4 mL in the aliquot tube.
Causes for Rejection
Improperly labeled or handled specimens might be rejected upon evaluation at Mayo Clinic Laboratories.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 14 days |
| Frozen | 30 days |