Protein, Total, Spinal Fluid

Casandra

Casandra Test Code MC13615Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID TPSFCPT Code 84157

Protein, Total, Spinal Fluid

Clinical Use

Use

The test for total protein in cerebrospinal fluid (CSF) is useful in detecting disruptions of the blood-brain barrier or intrathecal synthesis of immunoglobulins. Elevated levels of CSF protein are associated with conditions that compromise the integrity of the capillary endothelial barrier, such as meningitis, brain tumors, and cerebral infarction. These conditions lead to an increase in the total protein concentration in CSF due to plasma infiltration or neurological disease processes. The test is particularly useful in diagnosing and monitoring conditions like multiple sclerosis, encephalomyelitis, and various forms of meningitis.

Special Instructions

The test requires a CSF specimen, and it is important to centrifuge the specimen to remove any cellular material before submission. Specimens should be collected prior to the intrathecal administration of contrast media due to potential interference with test results.

Limitations

Increased CSF total protein is sensitive for detecting blood-brain barrier disruptions but is not specific for distinguishing between various causes. Hemolysis can falsely elevate protein levels, requiring interpretation with caution, particularly in cases involving traumatic lumbar puncture or CNS hemorrhagic processes. Presence of hemoglobin or blood in CSF can invalidate results. Positive bias from contrast media, such as Iopamidol, Iohexol, and Metrizamide, should be considered.

Test Details

FDA Approved