Psychotropic Pharmacogenomics Gene Panel, Varies
Use
This panel serves to individualize medication selection and dosing for patients undergoing treatment for depression and other psychiatric disorders, based on genetic variation. It identifies genetic factors associated with drug response and risk of adverse effects with psychotropic medications. The analysis may assist in determining the cause of unsuccessful SSRI treatment and evaluates treatment-resistant depression. It can also predict the time to response with SSRI therapy.
Special Instructions
Not provided.
Limitations
Specimens from patients who have received recent blood transfusions or stem cell transplants may reflect incorrect genotype results due to donor DNA presence. Post-transplant results may not indicate the patient's original genotype. The test does not provide explicit dosing recommendations and should be used to support clinical decision-making. Certain genetic variants may not be detected due to insufficient DNA quality from saliva specimens, possibly necessitating additional specimens for robust results.
New York Approved
Methodology
PCR-based (RT-PCR)
Biomarkers
LOINC Codes
- 94753-1 - Psychotropic Pharmg Analy Bld/T
- 94401-7 - ADRA2A c.-1252G>C Geno Bld/T
- 94402-5 - ANKK1 c.2137G>A Geno Bld/T
- 94403-3 - CHRNA3 c.645C>T Geno Bld/T
- 74511-7 - COMT c.1947G>A Geno Bld/T
- 72884-0 - CYP1A2 allele Geno Bld/T
- 94254-0 - CYP1A2 gene prod met act Bld/T-Imp
- 72882-4 - CYP2B6 allele Geno Bld/T
- 79720-9 - CYP2B6 gene prod met act imp Bld/T-Imp
- 104666-3 - CYP2B6 Activity Score Bld/T
- 57132-3 - CYP2C19 allele Geno Bld/T
- 79714-2 - CYP2C19 gene prod met act imp Bld/T-Imp
- 104667-1 - CYP2C19 Activity Score Bld/T
- 46724-1 - CYP2C9 allele Geno Bld/T
- 79716-7 - CYP2C9 gene prod met act imp Bld/T-Imp
- 104668-9 - CYP2C9 Activity Score Bld/T
- 40425-1 - CYP2D6 allele Geno Bld/T
- 79715-9 - CYP2D6 gene prod met act imp Bld/T-Imp
- 104669-7 - CYP2D6 Activity Score Bld/T
- 94411-6 - DRD2 c.-585A>G Geno Bld/T
- 94412-4 - EPHX1 c.416A>G Geno Bld/T
- 94413-2 - GRIK4 c.83-10039T>C Geno Bld/T
- 79712-6 - HLA-A*31:01 Bld/T Ql
- 57979-7 - HLA-B*15:02 Ql
- 93190-7 - HTR2A c.614-2211T>C Geno Bld/T
- 93191-5 - HTR2C c.-759C>T Geno Bld/T
- 93192-3 - HTR2C c.551-3008C>G Geno Bld/T
- 94414-0 - MTHFR c.677C>T + 1298A>C Geno Bld/T
- 94415-7 - OPRM1 c.118A>G Geno Bld/T
- 94416-5 - SCN1A c.603-91G>A Geno Bld/T
- 94417-3 - SLC6A4 5-HTTLPR Geno Bld/T
- 94418-1 - UGT2B15 c.253G>T Geno Bld/T
- 69047-9 - Geneticist review
- 48767-8 - Annotation comment Imp
- 85069-3 - Lab test method
- 62364-5 - Test performance info Spec
- 18771-6 - Provider signing name
- 81139-8 - CYP3A4 allele Geno Bld/T
- 81145-5 - CYP3A4 gene prod met act Bld/T-Imp
- 81140-6 - CYP3A5 allele Geno Bld/T
- 79717-5 - CYP3A5 gene prod met act imp Bld/T-Imp
Result Turnaround Time
3-14 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
3 mL
Minimum Volume
Not provided
Container
Lavender top (EDTA)
Collection Instructions
Invert several times to mix blood. Send whole blood specimen in original tube. Do not aliquot. Whole blood collected postnatal from umbilical cord is acceptable.
Patient Preparation
A previous hematopoietic stem cell transplant from an allogenic donor will interfere with testing.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 days |
| Refrigerated | 4 days |
| Frozen | 4 days |