Purkinje Cell Cytoplasmic Antibody, Type Tr (PCA-Tr) Titer, Spinal Fluid
Use
This test is useful for serological testing for Purkinje cell cytoplasmic antibody-Tr in patients with acquired cerebellar ataxia of undetermined etiology, particularly if there is a history of Hodgkin lymphoma. A positive result is an indicator of neurological autoimmunity and suggests a search for Hodgkin lymphoma since Purkinje cell cytoplasmic antibody-Tr is strongly associated with this condition.
Special Instructions
This test is not directly orderable and is available as a reflex. The test utilizes indirect immunofluorescence assay and is reported as an end titer result from spinal fluid specimens.
Limitations
Interference from coexisting autoantibodies may preclude interpretation of the immunofluorescence pattern. A negative result does not exclude neurological autoimmunity or Hodgkin lymphoma. The Purkinje cell cytoplasmic antibody-Tr antigen has not been defined immunochemically, and autoantibodies against glutamate receptors may occur in this context. No Western blot characteristics have been defined for the PCA-Tr antigen.
New York Approved
Methodology
Immunoassay (Indirect Immunofluorescence Assay (IFA))
Biomarkers
LOINC Codes
- 94362-1
- 94362-1
Result Turnaround Time
6-8 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
4 mL
Minimum Volume
2 mL
Container
Sterile vial
Causes for Rejection
Gross hemolysis, Gross lipemia, Gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 28 days |
| Frozen | 28 days |