Pyridoxic Acid, Plasma
Use
The test is useful for determining the concentration of pyridoxic acid in plasma as part of the assessment of vitamin B6 status. It helps in identifying vitamin B6 deficiency, which is associated with a range of symptoms such as skin scaling, gingivitis, and neurological issues. Elevated levels of PLP with low pyridoxic acid might indicate hypophosphatasia, a disorder with low alkaline phosphatase levels.
Special Instructions
This test is only orderable as part of a profile. Patients must fast for 12 hours prior to collection and avoid multivitamins or supplements for 24 hours before collection.
Limitations
Levels of pyridoxic acid alone are not clinically significant and must be interpreted alongside pyridoxal 5-phosphate (PLP) levels. Elevated PLP can be due to dietary supplementation, and additional testing may be required to distinguish between dietary effects and disorders such as hypophosphatasia.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 1688-1
- 1688-1
Result Turnaround Time
3-7 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL
Minimum Volume
0.75 mL
Container
Amber vial
Collection Instructions
Centrifuge at 4 degrees C within 2 hours of collection. Aliquot all plasma into amber vial and freeze immediately.
Patient Preparation
Fasting: 12 hours required; infants should have specimen collected before next feeding, water can be taken as needed. Avoid multivitamins/vitamin supplements for 24 hours before specimen collection.
Storage Instructions
Ship specimen in amber vial to protect from light.
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | 29 days |