Pyruvate, Spinal Fluid
Use
The test is useful for investigating possible disorders of mitochondrial metabolism when used alongside cerebrospinal fluid lactate measurements to calculate the lactate-to-pyruvate ratio (L:P). It assists in evaluating patients with neurological dysfunction and normal blood L:P ratios. The ratio aids in the assessment of patients suspected to have mitochondrial metabolism disorders, especially when neurological symptoms are present despite normal blood L:P ratios.
Special Instructions
Not provided.
Limitations
The test does not calculate the lactate-to-pyruvate ratio. Both tests PYRC (Pyruvic Acid, CSF) and LASF1 (Lactic Acid, Spinal Fluid) must be ordered together to derive this ratio. The L:P ratio is elevated in various mitochondrial respiratory chain disorders and can vary widely depending on the specific mitochondrial disorder, which often manifests with neurological symptoms, developmental delays, and, potentially, a range of multisystemic issues. A low L:P ratio is indicative of inherited disorders linked to pyruvate metabolism such as pyruvate dehydrogenase complex (PDHC) deficiency.
New York Approved
Methodology
Automated Analyzer (Clinical Chemistry Analyzer)
Biomarkers
Pyruvic Acid
Analyte
LOINC Codes
- 14122-6 - Pyruvate CSF-sCnc
- 14122-6 - Pyruvate CSF-sCnc
Result Turnaround Time
2-5 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
0.6 mL
Minimum Volume
0.5 mL
Container
Sterile vial
Collection Instructions
Send specimen from vial 4.
Causes for Rejection
Gross hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 7 days |
| Frozen | 14 days |