Rapid Plasma Reagin (RPR) Screen with Reflex to Titer, Serum
Use
This test is useful for determining the current status of syphilis disease and monitoring the response to treatment. It aids in diagnosing congenital syphilis when serum from both the mother and neonate is tested concurrently. The RPR test is part of the reverse syphilis screening algorithm, which initially uses an automated treponemal assay to detect antibodies specific to Treponema pallidum. A positive result triggers reflex testing with RPR, where a positive RPR indicates active or recent syphilis infection.
Special Instructions
Do not use this test as a primary diagnostic tool for syphilis. It is intended for monitoring purposes in treated patients and diagnosing congenital syphilis when maternal and neonate sera are tested together. For detecting undiagnosed syphilis, order the Syphilis IgG with Reflex, Enzyme Immunoassay test.
Limitations
This test cannot be used for testing spinal fluid specimens and is not intended for medical-legal use. Biological false-positive reactions may occur in conditions like infectious mononucleosis, leprosy, malaria, and autoimmune diseases, among others. False positives can also occur with other treponemal infections like pinta and yaws.
FDA ApprovedNew York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 20507-0
- 20507-0
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.4 mL
Container
Preferred: Serum gel; Acceptable: Red top
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis, Gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 14 days |
| Frozen | 14 days |