Use

The Rapid Plasma Reagin (RPR) test with reflex to Treponema pallidum Particle Agglutination (TP-PA) is primarily used for diagnosing syphilis. Syphilis, caused by the spirochete Treponema pallidum subspecies pallidum, is a systemic infection with periods of latency. Due to its systemic nature, serologic techniques are crucial for diagnosis and follow-up. This test is part of the reverse syphilis screening algorithm. If the initial treponemal antibody assay is positive, it reflexes to RPR testing. Positive RPR results suggest active or recent infection, while negative results reflex to the TP-PA test for confirmation.