Rat Serum Protein, IgE, Serum
Use
The test is useful for establishing a diagnosis of an allergy to rat serum protein. It assists in defining the allergen responsible for eliciting signs and symptoms. It also identifies allergens responsible for allergic responses and anaphylactic episodes, and confirms sensitization before immunotherapy. The test is part of the investigation of allergic reactions' specificity to insect venom allergens, drugs, or chemical allergens. However, testing for IgE antibodies is not beneficial for patients previously treated with immunotherapy to determine residual clinical sensitivity, or if the medical management does not depend on allergen specificity identification.
Special Instructions
For ordering, if not done electronically, complete and send an Allergen Test Request (T236) with the specimen. The preferred specimen collection containers are Serum gel tubes, with red top tubes being acceptable. After centrifugation, serum should be aliquoted into a plastic vial.
Limitations
The test has limitations regarding false positives due to non-specific binding in patients with markedly elevated serum IgE levels (>2500 kU/L). The results need to be interpreted within the clinical context as clinically insignificant sensitivity might present measurable IgE antibody levels. It is not useful for patients with previous treatments involving immunotherapy if clinical sensitivity or allergen specificity is not critical for management.
FDA ApprovedNew York Approved
Methodology
Immunoassay (FEIA)
Biomarkers
LOINC Codes
- 6225-7
- 6225-7
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL per 5 allergens
Minimum Volume
Not provided
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 14 days |
| Frozen | 90 days |