Renal Cell Carcinoma, 6p21.1 (TFEB) Rearrangement, FISH, Tissue
Use
This test is useful for identifying TFEB gene rearrangements, supporting the diagnosis of renal cell carcinoma when used in conjunction with an anatomic pathology consultation. TFEB gene rearrangements are associated with renal cell carcinoma and the fluorescence in situ hybridization (FISH) methodology allows for the detection of these rearrangements to aid in diagnosis.
Special Instructions
Not provided.
Limitations
This test is not FDA-approved and should be used as an adjunct to existing clinical and pathologic information. The test does not exclude other chromosome abnormalities and does not guarantee successful results on non-formalin fixed or decalcified tissue, with the latter having a success rate of about 50%. Probe application and analysis might incur additional charges, based on the number of cells analyzed. If no cells are available, no charges will be incurred. Ancillary probes may be performed at discretion for a comprehensive assessment.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
No genes
Gene
LOINC Codes
- 95780-3 - TFEB rearrange Tiss FISH
- 50397-9 - Mol dx interp Bld/T Ql
- 69965-2 - Clinical cytogeneticist review
- 62356-1 - Chrom analy result (ISCN)
- 42349-1
- 31208-2 - Specimen source
- 80398-1 - Unique ID Current sample
- 85069-3 - Lab test method
- 48767-8 - Annotation comment Imp
- 62364-5 - Test performance info Spec
- 18771-6 - Provider signing name
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Submit a formalin-fixed, paraffin-embedded (FFPE) tumor tissue block. Blocks prepared with alternative fixation methods will be attempted but are less favorable.
Storage Instructions
Ambient (preferred); Refrigerated (acceptable)