Retinol Binding Protein
Use
Retinol binding protein (RBP) is commonly used to assess nutritional status and to evaluate protein-energy malnutrition, particularly in the context of vitamin A deficiency. It serves as a transporter for vitamin A in the blood and is therefore integral to visual function, growth, and immune function. Clinicians may use RBP measurements to evaluate nutritional interventions and to monitor recovery in affected patients.
Special Instructions
Ensure the patient fasts for 12 hours prior to specimen collection. The preferred collection container is a red top tube, but a serum gel tube is also acceptable. After centrifugation, aliquot 2 mL of serum into a plastic vial and send the specimen refrigerated.
Limitations
The specificity and sensitivity of the retinol binding protein test can be influenced by factors like acute phase response, liver dysfunction, and nephrotic syndrome, which may alter serum protein levels or vitamin A status. Interpretation of results should consider these potential confounding factors, and results should be correlated with clinical findings and other laboratory tests. Hemolyzed, viscous, or improperly stored samples may lead to inaccurate results.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 1836-6
- 1836-6
Result Turnaround Time
3-7 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
0.5 mL
Container
Red top or serum gel tube
Collection Instructions
Centrifuge and aliquot 2 mL of serum into a plastic vial. Send refrigerated.
Patient Preparation
Fasting: 12 hours, required.
Storage Instructions
Refrigerated (preferred) up to 20 days, Frozen up to 180 days.
Causes for Rejection
Gross hemolysis, viscous or pleural fluid, received in glass tube, received at room temperature
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 20 days |
| Frozen | 180 days |