Rubeola (Measles) Antibodies, IgG and IgM, Spinal Fluid
Use
This test is useful for diagnosing central nervous system rubeola (measles) virus infection and subacute sclerosing panencephalitis (SSPE). Measles is a serious and highly contagious disease with complications developing in some children who otherwise appear to have normal immune function. SSPE is a rare, progressive, and typically fatal disease affecting the central nervous system, occurring in children years after measles infection. The detection of measles-specific antibodies in cerebrospinal fluid is critical in the diagnosis of SSPE.
Special Instructions
The specimen should be from collection vial number 2 (preferred), 3, or 4. If not ordering electronically, complete, print, and send the Infectious Disease Serology Test Request (T916) with the specimen.
Limitations
The detection of antibodies in cerebrospinal fluid (CSF) may suggest an infection, but results cannot distinguish between intrathecal antibodies and those introduced from serum at the time of lumbar puncture. It is crucial to interpret the results with other laboratory and clinical data to avoid confusion from improper specimen collection and interfering substances.
Methodology
Immunoassay (Immunofluorescence Assay (IFA))
Biomarkers
LOINC Codes
- 90254-4
- 22501-1
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
0.25 mL
Minimum Volume
0.1 mL
Container
Sterile vial
Collection Instructions
Submit specimen from collection vial number 2 (preferred), 3, or 4.
Causes for Rejection
Gross hemolysis and gross lipemia are acceptable conditions.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 14 days |
| Frozen | 14 days |