Sertraline (Zoloft) and Desmethylsertraline
Use
This test measures the concentration of Sertraline (Zoloft) and its active metabolite Desmethylsertraline in the blood to monitor therapeutic levels and ensure effective treatment while avoiding toxicity. It is used primarily in patients taking Sertraline to assess serum levels for optimal dosing. The testing helps in understanding patient compliance, drug-drug interactions, and patient metabolization rate which can vary significantly and affect drug efficacy and safety.
Special Instructions
Not provided.
Limitations
The test may not detect Sertraline or Desmethylsertraline levels outside of the provided reference intervals if improper specimen handling occurs. Hemolysis, lipemia, and icterus do not affect the test accuracy, but improper tubes can lead to rejection. The reference range for Desmethylsertraline is not well-defined, limiting interpretation.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
Desmethylsertraline
AnalyteSertraline
Analyte
LOINC Codes
- 78438-9 - Sertraline Trough + Nor Pnl SerPl
- 6906-2 - Sertraline SerPl-mCnc
- 6897-3 - Norsertraline SerPl-mCnc
Result Turnaround Time
3-7 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
2 mL
Minimum Volume
1.2 mL
Container
Green Top
Collection Instructions
Draw blood in a green-top (sodium heparin) tube, plasma gel tube not acceptable. Spin down and send 2 mL of sodium heparin plasma refrigerated in a plastic vial.
Causes for Rejection
SST
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 7 days |
| Frozen | 180 days |