Soluble Liver Antigen (SLA) Autoantibody
Use
Anti-soluble liver antigen antibodies are detected in 10-30% of patients with type 1 autoimmune hepatitis (AIH), but not in patients with type 2 AIH, primary sclerosing cholangitis or primary biliary cirrhosis. The antibody is directed against a UGA suppressor tRNA associated protein. In some patients with AIH, this antibody may be the only autoantibody detected by current assays.
Special Instructions
Test is performed on Wednesdays.
Limitations
Anti-SLA antibodies may be detected in some patients with the primary biliary cirrhosis-AIH overlap syndrome, but not in healthy controls. Reference values: Negative 0.0-20.0 U, Equivocal 20.1-24.9 U, Positive >25.0 U.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 32219-8
- 32219-8
Result Turnaround Time
2-13 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
Red or SST
Collection Instructions
Draw blood in a plain red-top tube(s), serum gel tube(s) is acceptable. Spin down and send 1 mL of serum refrigerated in a plastic vial.
Causes for Rejection
Microbially contaminated serum; Heavy visible particulate in specimen
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 8 days |
| Frozen | 28 days |